Solid medical reportage with a hopeful conclusion that science may soon bring a cure for a devastating disease.
The quest for a cure for Alzheimer’s in a perhaps unlikely venue.
Gabriel García Márquez’s novel One Hundred Years of Solitude detailed a number of genetic consequences of isolation, with hinterland families manifesting odd physical characteristics. The same isolation, Colombian researchers hypothesize, accounts for the pronounced presence of hereditary dementia there. As science writer Smith observes, there was the possibility that the Colombian countryside harbored “many potential triggers of dementia, including chemicals used in mining and agriculture.” Yet the fact that so many families had members with early-onset dementia, often setting in before age 50 and even younger, suggested a genetic cause—and one early discovery was that “every sick person had had a sick parent.” In a time of civil war and narco kings, medical research in Colombia was a fraught proposition, with investigators including one hero of the piece, a doctor named Francisco Lopera Restrepo, taking shelter abroad for a time as colleagues and students were kidnapped and murdered. When things calmed down, foreign scientists arrived to study the phenomenon alongside homegrown researchers, isolating genes and eventually helping establish clear patterns of inheritance—and, interestingly, also accumulating proof that trauma of some sort often proved a trigger in setting off a patient’s decline. Frustratingly, drugs used in extensive trials did not prove efficacious at first, though Big Pharma kept an eye open for the possibilities of a market in Colombia, “a common, and frequently criticized, practice among pharmaceutical firms working in the developing world: testing expensive therapies in poor populations, then passing the costs on to strapped healthcare systems.” The quest continues: As Smith writes in closing, the Colombian institute called Neurociencias has been an important pioneer in identifying numerous genetic mutations that may in time yield keys to treatment.
Solid medical reportage with a hopeful conclusion that science may soon bring a cure for a devastating disease.Pub Date: April 1, 2025
ISBN: 9780525536079
Page Count: 384
Publisher: Riverhead
Review Posted Online: Jan. 17, 2025
Kirkus Reviews Issue: Feb. 15, 2025
BOOK REVIEW
A determined if self-regarding portrait of a candidate striving to define herself and her campaign on her own terms.
An insider’s chronicle of a pivotal presidential campaign.
Several months into the mounting political upheaval of Donald Trump’s second term and following a wave of bestselling political exposés, most notably Jake Tapper and Alex Thompson’s Original Sin on Joe Biden’s health and late decision to step down, former Vice President Harris offers her own account of the consequential months surrounding Biden’s withdrawal and her swift campaign for the presidency. Structured as brief chapters with countdown headers from 107 days to Election Day, the book recounts the campaign’s daily rigors: vetting a running mate, navigating back-to-back rallies, preparing for the convention and the debate with Trump, and deflecting obstacles in the form of both Trump’s camp and Biden’s faltering team. Harris aims to set the record straight on issues that have remained hotly debated. While acknowledging Biden’s advancing decline, she also highlights his foreign-policy steadiness: “His years of experience in foreign policy clearly showed….He was always focused, always commander in chief in that room.” More blame is placed on his inner circle, especially Jill Biden, whom Harris faults for pushing him beyond his limits—“the people who knew him best, should have realized that any campaign was a bridge too far.” Throughout, she highlights her own qualifications and dismisses suggestions that an open contest might have better served the party: “If they thought I was down with a mini primary or some other half-baked procedure, I was quick to disabuse them.” Facing Trump’s increasingly unhinged behavior, Harris never openly doubts her ability to confront him. Yet she doesn’t fully persuade the reader that she had the capacity to counter his dominance, suggesting instead that her defeat stemmed from a lack of time—a theme underscored by the urgency of the book’s title. If not entirely sanguine about the future, she maintains a clear-eyed view of the damage already done: “Perhaps so much damage that we will have to re-create our government…something leaner, swifter, and much more efficient.”
A determined if self-regarding portrait of a candidate striving to define herself and her campaign on her own terms.Pub Date: Sept. 23, 2025
ISBN: 9781668211656
Page Count: 320
Publisher: Simon & Schuster
Review Posted Online: Sept. 23, 2025
Kirkus Reviews Issue: Nov. 15, 2025
BOOK REVIEW
BOOK REVIEW
Dogged original research and superb narrative skills come together in this gripping account of pitiless evil.
Greed, depravity, and serial murder in 1920s Oklahoma.
During that time, enrolled members of the Osage Indian nation were among the wealthiest people per capita in the world. The rich oil fields beneath their reservation brought millions of dollars into the tribe annually, distributed to tribal members holding "headrights" that could not be bought or sold but only inherited. This vast wealth attracted the attention of unscrupulous whites who found ways to divert it to themselves by marrying Osage women or by having Osage declared legally incompetent so the whites could fleece them through the administration of their estates. For some, however, these deceptive tactics were not enough, and a plague of violent death—by shooting, poison, orchestrated automobile accident, and bombing—began to decimate the Osage in what they came to call the "Reign of Terror." Corrupt and incompetent law enforcement and judicial systems ensured that the perpetrators were never found or punished until the young J. Edgar Hoover saw cracking these cases as a means of burnishing the reputation of the newly professionalized FBI. Bestselling New Yorkerstaff writer Grann (The Devil and Sherlock Holmes: Tales of Murder, Madness, and Obsession, 2010, etc.) follows Special Agent Tom White and his assistants as they track the killers of one extended Osage family through a closed local culture of greed, bigotry, and lies in pursuit of protection for the survivors and justice for the dead. But he doesn't stop there; relying almost entirely on primary and unpublished sources, the author goes on to expose a web of conspiracy and corruption that extended far wider than even the FBI ever suspected. This page-turner surges forward with the pacing of a true-crime thriller, elevated by Grann's crisp and evocative prose and enhanced by dozens of period photographs.
Dogged original research and superb narrative skills come together in this gripping account of pitiless evil.Pub Date: April 18, 2017
ISBN: 978-0-385-53424-6
Page Count: 352
Publisher: Doubleday
Review Posted Online: Feb. 1, 2017
Kirkus Reviews Issue: Feb. 15, 2017
BOOK TO SCREEN
BOOK TO SCREEN
BOOK TO SCREEN
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