Credit Gessen with absorbing gobs of information, but this is a case in which a little learning may be a dangerous thing—for...
Unsettling medical memoir by a worried-but-still-well journalist who carries a breast-cancer gene.
Gessen (Ester and Ruzya: How My Grandmothers Survived Hitler's War and Stalin’s Peace, 2004, etc.) has steeped herself in genetics lore—and conjecture—in this wide-ranging account of genetic information past, present and future. Her own story is often the focus, as she relates the deaths of her mother and other relatives from breast or ovarian cancers and traces the inheritance of the BRCA1 gene to her great-great-grandmother. The mother of one adopted and one biological child, she is considering having another baby, but the genetic counselor she consults advises an ovariectomy and perhaps a double mastectomy. As Gessen wrestles with decision-making, the text increasingly leans toward a deterministic view of genetic destiny: The BRCA genes do not simply increase the odds of cancer; they cause it, with more stubborn forms occurring at an earlier age. This pessimism colors her account as she reviews the history of genetics from the horrors of eugenics and Nazism to the discovery of the gene for the sickle-cell trait, which persists in the population because it increases protection against malaria. There is much discussion of Ashkenazi Jews and their genetic load of diseases, as well as the genetic problems of other groups. She lauds the clinicians who work with Amish and Mennonite groups in Pennsylvania, developing diets to stave off the worse effects of inherited metabolic diseases. Gessen rightly addresses such issues as the reliability of the new genome-testing firms and the value of tests in cases like Huntington’s, where the disease is inevitable but as yet untreatable in carriers. But the text is again disturbing as she moves on to discuss controversial behavior-related genes, even pondering whether her young son’s Russian heritage may make him vulnerable to alcoholism.
Credit Gessen with absorbing gobs of information, but this is a case in which a little learning may be a dangerous thing—for the author and her readers.Pub Date: April 1, 2008
ISBN: 978-0-15-101362-3
Page Count: 320
Publisher: Harcourt
Review Posted Online: June 24, 2010
Kirkus Reviews Issue: Feb. 1, 2008
The author's youthfulness helps to assure the inevitable comparison with the Anne Frank diary although over and above the...
Elie Wiesel spent his early years in a small Transylvanian town as one of four children.
He was the only one of the family to survive what Francois Maurois, in his introduction, calls the "human holocaust" of the persecution of the Jews, which began with the restrictions, the singularization of the yellow star, the enclosure within the ghetto, and went on to the mass deportations to the ovens of Auschwitz and Buchenwald. There are unforgettable and horrifying scenes here in this spare and sombre memoir of this experience of the hanging of a child, of his first farewell with his father who leaves him an inheritance of a knife and a spoon, and of his last goodbye at Buchenwald his father's corpse is already cold let alone the long months of survival under unconscionable conditions.
Pub Date: Jan. 16, 2006
ISBN: 0374500010
Page Count: 120
Publisher: Hill & Wang
Review Posted Online: Oct. 7, 2011
Kirkus Reviews Issue: Jan. 15, 2006
A moving meditation on mortality by a gifted writer whose dual perspectives of physician and patient provide a singular...
A neurosurgeon with a passion for literature tragically finds his perfect subject after his diagnosis of terminal lung cancer.
Writing isn’t brain surgery, but it’s rare when someone adept at the latter is also so accomplished at the former. Searching for meaning and purpose in his life, Kalanithi pursued a doctorate in literature and had felt certain that he wouldn’t enter the field of medicine, in which his father and other members of his family excelled. “But I couldn’t let go of the question,” he writes, after realizing that his goals “didn’t quite fit in an English department.” “Where did biology, morality, literature and philosophy intersect?” So he decided to set aside his doctoral dissertation and belatedly prepare for medical school, which “would allow me a chance to find answers that are not in books, to find a different sort of sublime, to forge relationships with the suffering, and to keep following the question of what makes human life meaningful, even in the face of death and decay.” The author’s empathy undoubtedly made him an exceptional doctor, and the precision of his prose—as well as the moral purpose underscoring it—suggests that he could have written a good book on any subject he chose. Part of what makes this book so essential is the fact that it was written under a death sentence following the diagnosis that upended his life, just as he was preparing to end his residency and attract offers at the top of his profession. Kalanithi learned he might have 10 years to live or perhaps five. Should he return to neurosurgery (he could and did), or should he write (he also did)? Should he and his wife have a baby? They did, eight months before he died, which was less than two years after the original diagnosis. “The fact of death is unsettling,” he understates. “Yet there is no other way to live.”
A moving meditation on mortality by a gifted writer whose dual perspectives of physician and patient provide a singular clarity.Pub Date: Jan. 19, 2016
ISBN: 978-0-8129-8840-6
Page Count: 248
Publisher: Random House
Review Posted Online: Sept. 29, 2015
Kirkus Reviews Issue: Oct. 15, 2015
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